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(Elysse Feigenblatt/Leafly) Hot Topics Air Conditioners Jason McDougall, who chairs the scientific advisory committee at the Arthritis Society, states, “It appears cannabis is not just dampening the pain in the brain, it’s actually working on the joint itself.” Our oral applicators offer the highest concentration of CBD per serving of any of our CBD products. 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Interestingly, the single dose of CBD led the men to experience a smaller blood pressure increase than normal in response to these tests (34). When ingested orally, however, THC and other cannabinoids and terpenes are absorbed from the small intestine over several hours. THC and the other constituents are then carried to the liver, where THC is metabolized by subclasses of cytochrome P450 enzyme (abbreviated CYP), specifically the CYP2C and CYP3A enzymes. About 85% of the THC is metabolized on its first pass through the liver. Like any oral medication, it will take about 45-75 minutes before enough of the plant constituents are in the bloodstream to exert a therapeutic effect. Further, there will be a greater effect of a THC metabolic breakdown product, 11-hydroxy-THC. The therapeutic potential of cannabidiol, one of the major phytochemicals found in marijuana, was largely ignored by doctors and scientists for decades. 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